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phenobarbital raises toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers might boost the metabolism of ifosfamide to its Energetic alkylating metabolites.This mechanism is probably through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital an